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- Title
Methylsulfinyl Hexyl Isothiocyanate (6-MSITC) from Wasabi Is a Promising Candidate for the Treatment of Cancer, Alzheimer's Disease, and Obesity.
- Authors
Bartkowiak-Wieczorek, Joanna; Malesza, Michał; Malesza, Ida; Hadada, Tomasz; Winkler-Galicki, Jakub; Grzelak, Teresa; Mądry, Edyta
- Abstract
Methylsulfinyl hexyl isothiocyanate (6-MSITC) isolated from Eutrema japonicum is a promising candidate for the treatment of breast cancer, colorectal and stomach cancer, metabolic syndrome, heart diseases, diabetes, and obesity due to its anti-inflammatory and antioxidant properties. Also, its neuroprotective properties, improving cognitive function and protecting dopaminergic neurons, make it an excellent candidate for treating neurodegenerative diseases like dementia, Alzheimer's, and Parkinson's disease. 6-MSITC acts on many signaling pathways, such as PPAR, AMPK, PI3K/AKT/mTOR, Nrf2/Keap1-ARE, ERK1/2-ELK1/CHOP/DR5, and MAPK. However, despite the very promising results of in vitro and in vivo animal studies and a few human studies, the molecule has not yet been thoroughly tested in the human population. Nonetheless, wasabi should be classified as a "superfood" for the primary and secondary prevention of human diseases. This article reviews the current state-of-the-art research on 6-MSITC and its potential clinical uses, discussing in detail the signaling pathways activated by the molecule and their interactions.
- Subjects
THERAPEUTIC use of antioxidants; DRUG therapy for heart diseases; HORSERADISH; ANTI-inflammatory agents; MITOGEN-activated protein kinases; NEUROPROTECTIVE agents; ALZHEIMER'S disease; STOMACH tumors; BREAST tumors; PHYTOCHEMICALS; CELLULAR signal transduction; TREATMENT effectiveness; COLORECTAL cancer; AMP-activated protein kinases; MOLECULAR structure; METABOLIC syndrome; MTOR inhibitors; TUMORS; PEROXISOME proliferator-activated receptors; OBESITY; DIABETES; NUCLEAR factor E2 related factor; COGNITION
- Publication
Nutrients, 2024, Vol 16, Issue 15, p2509
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16152509