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- Title
Assessment of Biochemical, Inflammatory Biomarkers and Ultra-Processed Food Consumption in Children with Small Intestinal Bacterial Overgrowth: A Cross-Sectional Study.
- Authors
Costa, Paulo César Trindade; Duarte, Davyson Barbosa; Viana das Neves, Thallyta Alanna Ferreira; Moraes, Rúbia Cartaxo Squizato de; Toscano, Lydiane de Lima Tavares; Arruda Neta, Adélia da Costa Pereira de; Baccin Martins, Vinicius José; de Brito Alves, José Luiz
- Abstract
Objective: This study evaluated anthropometric, biochemical, and inflammatory biomarkers, as well as dietary intake in Brazilian children diagnosed with small intestinal bacterial overgrowth (SIBO) and compared them with their counterparts without SIBO. Methods: This was a cross-sectional study with 106 children aged 7 to 10 years. A glucose-hydrogen breath test was performed to diagnose small intestinal bacterial overgrowth (SIBO). Anthropometric and dietary characteristics were assessed. Blood samples were collected and serum biochemical parameters and cytokines were measured. Results: The occurrence of SIBO was 13.2%. Age, BMI, BMI/age WC, BFP, sex and biochemical markers were similar between SIBO-positive and SIBO-negative children (p > 0.05). High consumption of ultra-processed foods tended to be higher in SIBO-positive compared to SIBO-negative children (47.8 ± 8.2 vs. 42.6 ± 9.5, p = 0.06). Serum levels of IL-17 were higher in SIBO-positive than in SIBO-negative children [69.5 (5.4–125.7) vs. 53.4 (2.3–157.7), p = 0.03], while serum levels of IL-10 were lower in SIBO-positive than in SIBO-negative children [2.3 (0.6–7.2) vs. 5.7 (0.5–30.8), p = 0.04]. Finally, in a logistic regression adjusted for sex, BMI and age, consumption of ultra-processed foods (p = 0.03) and IL-6 levels (p = 0.003) were found to contribute to the occurrence of SIBO. Conclusion: this study identified for the first time an occurrence of 13% of SIBO in children living in the northeastern region of Brazil and showed that consumption of ultra-processed foods and serum levels of IL-6 may influence the occurrence of the SIBO in the pediatrics population.
- Subjects
BRAZIL; BLOOD testing; DIAGNOSIS of bacterial diseases; CROSS-sectional method; PACKAGED foods; FOOD consumption; RESEARCH funding; BODY mass index; LOGISTIC regression analysis; SEX distribution; DESCRIPTIVE statistics; AGE distribution; BRAZILIANS; ANTHROPOMETRY; INFLAMMATION; CYTOKINES; SMALL intestine; BIOMARKERS; INTERLEUKINS; CHILDREN
- Publication
Nutrients, 2024, Vol 16, Issue 15, p2477
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16152477