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- Title
Human Milk Oligosaccharides, Growth, and Body Composition in Very Preterm Infants.
- Authors
Ong, Margaret L.; Cherkerzian, Sara; Bell, Katherine A.; Berger, Paige K.; Furst, Annalee; Sejane, Kristija; Bode, Lars; Belfort, Mandy B.
- Abstract
Human milk oligosaccharides (HMOs) are bioactive factors that benefit neonatal health, but little is known about effects on growth in very preterm infants (<32 weeks' gestation). We aimed to quantify HMO concentrations in human milk fed to very preterm infants during the neonatal hospitalization and investigate associations of HMOs with infant size and body composition at term-equivalent age. In 82 human-milk-fed very preterm infants, we measured HMO concentrations at two time points. We measured anthropometrics and body composition with air displacement plethysmography at term-equivalent age. We calculated means of individual and total HMOs, constructed tertiles of mean HMO concentrations, and assessed differences in outcomes comparing infants in the highest and intermediate tertiles with the lowest tertile using linear mixed effects models, adjusted for potential confounders. The mean (SD) infant gestational age was 28.2 (2.2) weeks, and birthweight was 1063 (386) grams. Exposure to the highest (vs. lowest) tertile of HMO concentrations was not associated with anthropometric or body composition z-scores at term-corrected age. Exposure to the intermediate (vs. lowest) tertile of 3FL was associated with a greater head circumference z-score (0.61, 95% CI 0.15, 1.07). Overall, the results do not support that higher HMO intakes influence growth outcomes in this very preterm cohort.
- Subjects
OLIGOSACCHARIDE analysis; PLETHYSMOGRAPHY; INFANTS; BODY composition; HOSPITAL care; MULTIPLE regression analysis; BREAST milk; NUTRITIONAL requirements; DESCRIPTIVE statistics; LONGITUDINAL method; GESTATIONAL age; CHILD development; BIRTH weight; COMPARATIVE studies; CONFIDENCE intervals
- Publication
Nutrients, 2024, Vol 16, Issue 8, p1200
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16081200