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- Title
Magnesium and the Hallmarks of Aging.
- Authors
Dominguez, Ligia J.; Veronese, Nicola; Barbagallo, Mario
- Abstract
Magnesium is an essential ion in the human body that regulates numerous physiological and pathological processes. Magnesium deficiency is very common in old age. Age-related chronic diseases and the aging process itself are frequently associated with low-grade chronic inflammation, called 'inflammaging'. Because chronic magnesium insufficiency has been linked to excessive generation of inflammatory markers and free radicals, inducing a chronic inflammatory state, we formerly hypothesized that magnesium inadequacy may be considered among the intermediaries helping us explain the link between inflammaging and aging-associated diseases. We show in this review evidence of the relationship of magnesium with all the hallmarks of aging (genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, disabled autophagy, dysbiosis, and chronic inflammation), which may positively affect the human healthspan. It is feasible to hypothesize that maintaining an optimal balance of magnesium during one's life course may turn out to be a safe and economical strategy contributing to the promotion of healthy aging. Future well-designed studies are necessary to further explore this hypothesis.
- Subjects
HOMEOSTASIS; HYPOMAGNESEMIA; ACTIVE aging; PROTEIN metabolism disorders; CHRONIC diseases; FOOD consumption; AUTOPHAGY; GUT microbiome; INFLAMMATION; IATROGENIC diseases; GENETIC variation; MITOCHONDRIA; CELLULAR aging; MAGNESIUM; STEM cells; MOLECULAR structure; EPIGENOMICS; DISEASE complications; SYMPTOMS
- Publication
Nutrients, 2024, Vol 16, Issue 4, p496
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16040496