We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China.
- Authors
Han, Weiling; Zheng, Wei; Wang, Aili; Chen, Junxi; Wang, Jia; Huang, Junhua; An, Hang; Ma, Yuru; Zhang, Kexin; Yang, Ruihua; Yan, Lailai; Li, Zhiwen; Li, Guanghui
- Abstract
We performed this study to clarify the dynamic changes in maternal manganese (Mn) concentration during pregnancy and its association with spontaneous preterm birth (SPB). A nested case–control study was conducted based on the Beijing Birth Cohort Study (BBCS) from 2018 to 2020. Singleton pregnancy women aged 18–44 (n = 488) were involved in the study, including 244 cases of SPB and 244 controls. All of the participants provided blood samples twice (in their first and third trimesters). Inductively coupled plasma mass spectrometry (ICP-MS) was used for the laboratory analysis, and unconditional logistic regression was used for the statistical analysis. We found that the maternal Mn levels were significantly higher in the third trimester than those in the first trimester (median: 1.23 vs. 0.81 ng/mL). The SPB risk was increased to 1.65 (95% CI: 1.04–2.62, p = 0.035) in the highest Mn level (third tertile) in the third trimester, especially in normal-weight women (OR: 2.07, 95% CI: 1.18–3.61, p = 0.011) or non-premature rupture of membrane (PROM) women (OR: 3.93, 95% CI: 2.00–7.74, p < 0.001). Moreover, a dose-dependent relationship exists between the SPB risk and maternal Mn concentration in non-PROM women (P trend < 0.001). In conclusion, dynamic monitoring of maternal Mn level during pregnancy would be helpful for SPB prevention, especially in normal-weight and non-PROM women.
- Subjects
CHINA; MATERNAL exposure; PREMATURE infants; CONFIDENCE intervals; CASE-control method; MANGANESE; RISK assessment; PATIENT monitoring; MASS spectrometry; REPEATED measures design; RESEARCH funding; LOGISTIC regression analysis; ODDS ratio; PREGNANCY
- Publication
Nutrients, 2023, Vol 15, Issue 6, p1413
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15061413