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- Title
Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis.
- Authors
Zhang, Zhanzhi; Zhang, Yu; Tao, Xiaomei; Wang, Yuying; Rao, Benqiang; Shi, Hanping
- Abstract
The hypoglycemic and lipid-lowering effects of glucomannan are widely known, and it is a potential effective treatment for type II diabetes. In this study, we evaluated the effects of glucomannan supplementation on blood-lipid-related indicators, blood-glucose-related indicators, blood pressure (BP), and body weight (BW) in patients suffering from type II diabetes. We searched databases including PubMed, Cochrane, the comprehensive biomedical research database (Embase), Web of Science, and China National Knowledge Infrastructure (CNKI) for literature on glucomannan and type II diabetes. Six randomized controlled trials (RCTs) were eligible (n = 440 participants) to be included in our analysis. Glucomannan not only reduced the total cholesterol (TC) (MD −0.38 [95% CI: −0.61, −0.15], p = 0.001) and low-density lipoprotein (LDL) levels (MD −0.35 [95% CI: −0.52, −0.17], p < 0.0001) compared with the control group, but also reduced the fasting blood glucose (FBG) (MD −1.08 [95% CI: −1.65, −0.50], p = 0.0002), 2 h postprandial blood glucose (P2hBG) (MD −1.92 [95% CI: −3.19, −0.65], p = 0.003), fasting insulin (FINS) (MD −1.59 [95% CI: −2.69, −0.50], p = 0.004), and serum fructosamine (SFRA) levels (SMD −1.19 [95% CI: −1.74, −0.64], p < 0.0001). Our analysis indicates that glucomannan is an effective nutritional intervention for type II diabetes.
- Subjects
POLYSACCHARIDES; BLOOD pressure; ONLINE information services; MEDICAL databases; FASTING; KEY performance indicators (Management); BODY weight; META-analysis; MEDICAL information storage &; retrieval systems; CONFIDENCE intervals; SYSTEMATIC reviews; FOOD consumption; BLOOD sugar; LOW density lipoproteins; DIETARY supplements; TYPE 2 diabetes; TREATMENT effectiveness; COMPARATIVE studies; INSULIN; CLINICAL medicine; RESEARCH funding; DESCRIPTIVE statistics; MOLECULAR structure; MEDLINE; LIPIDS; CHOLESTEROL
- Publication
Nutrients, 2023, Vol 15, Issue 3, p601
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15030601