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- Title
Lipid Metabolism in Cartilage Development, Degeneration, and Regeneration.
- Authors
Su, Zhanpeng; Zong, Zhixian; Deng, Jinxia; Huang, Jianping; Liu, Guihua; Wei, Bo; Cui, Liao; Li, Gang; Zhong, Huan; Lin, Sien
- Abstract
Lipids affect cartilage growth, injury, and regeneration in diverse ways. Diet and metabolism have become increasingly important as the prevalence of obesity has risen. Proper lipid supplementation in the diet contributes to the preservation of cartilage function, whereas excessive lipid buildup is detrimental to cartilage. Lipid metabolic pathways can generate proinflammatory substances that are crucial to the development and management of osteoarthritis (OA). Lipid metabolism is a complicated metabolic process involving several regulatory systems, and lipid metabolites influence different features of cartilage. In this review, we examine the current knowledge about cartilage growth, degeneration, and regeneration processes, as well as the most recent research on the significance of lipids and their metabolism in cartilage, including the extracellular matrix and chondrocytes. An in-depth examination of the involvement of lipid metabolism in cartilage metabolism will provide insight into cartilage metabolism and lead to the development of new treatment techniques for metabolic cartilage damage.
- Subjects
LIPID metabolism; CARTILAGE physiology; CHOLESTEROL metabolism; HOMEOSTASIS; CARTILAGE cells; CHONDROGENESIS; REGENERATION (Biology); OSTEOARTHRITIS; PHOSPHOLIPIDS; FATTY acids
- Publication
Nutrients, 2022, Vol 14, Issue 19, p3984
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14193984