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- Title
Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults.
- Authors
Thota, Rohith N.; Rosato, Jessica I.; Burrows, Tracy L.; Dias, Cintia B.; Abbott, Kylie A.; Martins, Ralph N.; Garg, Manohar L.
- Abstract
Targeting kinases linked to insulin resistance (IR) and inflammation may help in reducing the risk of type 2 diabetes (T2D) and Alzheimer's disease (AD) in its early stages. This study aimed to determine whether DHA-rich fish oil supplementation reduces glycogen synthase kinase (GSK-3), which is linked to both IR and AD. Baseline and post-intervention plasma samples from 58 adults with abdominal obesity (Age: 51.7 ± 1.7 years, BMI: 31.9 ± 0.8 kg/m2) were analysed for outcome measures. Participants were allocated to 2 g DHA-rich fish oil capsules (860 mg DHA + 120 mg EPA) (n = 31) or placebo capsules (n = 27) per day for 12 weeks. Compared to placebo, DHA-rich fish oil significantly reduced GSK-3β by −2.3 ± 0.3 ng/mL. An inverse correlation (p < 0.05) was found between baseline insulin and IR and their changes following intervention only in participants with C-reactive protein levels higher than 2.4 mg/L. DHA-rich fish oil reduces GSK-3 and IR, suggesting a potential role of long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) in ameliorating AD risk.
- Subjects
ALZHEIMER'S disease; BLOOD plasma; C-reactive protein; DIETARY supplements; FISH oils; INSULIN; INSULIN resistance; TYPE 2 diabetes; OBESITY; OMEGA-3 fatty acids; TRANSFERASES; DOCOSAHEXAENOIC acid
- Publication
Nutrients, 2020, Vol 12, Issue 6, p1612
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12061612