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- Title
The Effect of Increasing the Protein Content of Human Milk Fortifier to 1.8 g/100 mL on Growth in Preterm Infants: A Randomised Controlled Trial.
- Authors
Reid, Jessica; Makrides, Maria; McPhee, Andrew J.; Stark, Michael J.; Miller, Jacqueline; Collins, Carmel T.
- Abstract
The aim of this study was to assess the effect of feeding high protein human milk fortifier (HMF) on growth in preterm infants. In this single-centre randomised trial, 60 infants born 28–32 weeks’ gestation were randomised to receive a higher protein HMF providing 1.8 g protein (<italic>n</italic> = 31) or standard HMF providing 1 g protein per 100 mL expressed breast milk (EBM) (<italic>n</italic> = 29). The primary outcome was rate of weight gain. Baseline characteristics were similar between groups. There was no difference between high and standard HMF groups for weight gain (mean difference (MD) −14 g/week; 95% CI −32, 4; <italic>p</italic> = 0.12), length gain (MD −0.01 cm/week; 95% CI −0.06, 0.03; <italic>p</italic> = 0.45) or head circumference gain (MD 0.007 cm/week; 95% CI −0.05, 0.06; <italic>p</italic> = 0.79), despite achieving a 0.7 g/kg/day increase in protein intake in the high protein group. Infants in the high protein group had a higher proportion of lean body mass at trial entry; however, there was no group by time effect on lean mass gains over the study. Increasing HMF protein content to 1.8 g per 100 mL EBM does not improve growth in preterm infants born 28–32 weeks’ gestation.
- Subjects
BREAST milk; CEPHALOMETRY; CONFIDENCE intervals; GESTATIONAL age; INFANTS; PREMATURE infants; INFANT development; INFANT nutrition; LACTATION; MILK proteins; NUTRITIONAL requirements; WEIGHT gain; BODY mass index; RANDOMIZED controlled trials
- Publication
Nutrients, 2018, Vol 10, Issue 5, p634
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10050634