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- Title
αCGRP-Induced Changes in Cerebral and Systemic Circulation; A TCD Study.
- Authors
Visočnik, Darja; Žvan, Bojana; Zaletel, Marjan; Zupan, Matija
- Abstract
It is known that perivascular application of CGRP induces cerebral vasodilatation. However, it is unclear whether intravenous alfa CGRP (aCGRP) induces changes in cerebral and systemic hemodynamics. Therefore, we studied the influence of an aCGRP intravenous infusion at a rate of 1.5 mcg/min in 20min on mean arterial velocity in the middle cerebral artery (vm MCA) and in the posterior cerebral artery (vm PCA) in twenty healthy subjects using transcranial Doppler (TCD). We found out that aCGRP decreased vm MCA (p < 0.001), vm PCA (p < 0.001), mean arterial pressure (MAP) (p < 0.001) and end-tidal CO2 (Et-CO2) (p = 0.030). The heart rate (HR) increased during αCGRP infusion (p < 0.001). In addition, we found a positive relationship between Et-CO2 and vm MCA (p = 0.001) as well as vm PCA (p = 0.043). In our view, aCGRP induces changes in cerebral and systemic circulation in healthy volunteers. It might cause vasodilatation of MCA and PCA and a compensatory decrease of Et-CO2 to aCGRP related hemodynamic changes.
- Subjects
CEREBRAL circulation; POSTERIOR cerebral artery; HEART beat; TRANSCRANIAL Doppler ultrasonography; VASODILATION
- Publication
Frontiers in Neurology, 2024, p1
- ISSN
1664-2295
- Publication type
Article
- DOI
10.3389/fneur.2020.578103