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- Title
Effects of new over-the-counter periodontal ointment-containing applicator with single-tuft brush on cytokine levels in gingival crevicular fluid during supportive periodontal therapy phase: a randomized double-blind clinical trial.
- Authors
Takeuchi‐Hatanaka, K.; Yasuda, T.; Naruishi, K.; Katsuragi‐Fuke, K.; Inubushi, J.; Ootsuki, H.; Maeda, H.; Takashiba, S.
- Abstract
Background and Objective The biochemical effects of an over-the-counter ( OTC) medication were studied, which consists of a single-tuft brush containing cetylpyridinium chloride as a bactericidal agent, dipotassium glycyrrhizate as an anti-inflammatory drug and allantoin as a promoter of cell proliferation and wound healing, for delivery to hardly brushed sites. Material and Methods This randomized controlled double-blind study was performed in 61 subjects with chronic periodontitis in supportive periodontal therapy phase (test group: n = 27; placebo group: n = 28; dropout: n = 6). The OTC medication was self-applied twice a day for 12 wk to two molars with probing pocket depths of 4-6 mm. Biochemical indicators were evaluated at baseline and 12 wk using the suspension array system for eight cytokines and chemokines (interleukin [ IL]-1β, IL-1ra, IL-4, IL-6, IL-8, IL-10, monocyte chemoattractant protein-1 and tumor necrosis factor [ TNF]-α) in gingival crevicular fluid. Results The levels of IL-1β, IL-6, IL-8 and TNF-α remained significantly lower in the test group compared to the placebo group. In the placebo group, when the probing pocket depth at baseline was 4 mm, IL-1β increased, particularly in the second molar tooth, and the greatest increase was seen when PPD at baseline was 5-6 mm. In the test group, IL-1β decreased markedly in cases with furcation involvement and low bleeding on probing at baseline. In both groups, IL-1β, IL-6 and TNF-α were closely correlated with each other. Conclusion This OTC medication is biochemically effective for steady chronic periodontitis in the supportive periodontal therapy phase.
- Subjects
SALIVA analysis; CHI-squared test; STATISTICAL correlation; CYTOKINES; NONPRESCRIPTION drugs; FISHER exact test; RESEARCH funding; STATISTICS; T-test (Statistics); DATA analysis; RANDOMIZED controlled trials; BLIND experiment; MANN Whitney U Test; ONE-way analysis of variance; FRIEDMAN test (Statistics)
- Publication
Journal of Periodontal Research, 2016, Vol 51, Issue 3, p321
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/jre.12311