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- Title
Prognostic impact of CD5 expression in diffuse large B-cell lymphoma in patients treated with rituximab- EPOCH.
- Authors
Thakral, Beenu; Medeiros, L. Jeffrey; Desai, Parth; Lin, Pei; Yin, C. Cameron; Tang, Guilin; Khoury, Joseph D.; Hu, Shimin; Xu, Jie; Loghavi, Sanam; Hu, Bei; Oki, Yasuhiro; Li, Shaoying
- Abstract
Objectives CD5-positive ( CD5+) diffuse large B-cell lymphoma ( DLBCL) represents 5%-10% of all DLBCL cases, which has been associated with a poorer prognosis in patients treated with R- CHOP. Prognostic impact of CD5 expression in patients with DLBCL treated with R- EPOCH has not been evaluated. Methods We studied 130 patients with de novo DLBCL who received frontline R- EPOCH therapy. The clinicopathologic features and overall survival ( OS) were compared between patients with CD5+ and CD5- DLBCL. MYC, BCL2, and BCL6 rearrangements were examined by fluorescent in situ hybridization. Results Sixteen (12.3%) of 130 DLBCLs were CD5+. Most clinicopathologic features including cell of origin and frequency of MYC, BCL2, and BCL6 rearrangements were similar between CD5+ and CD5− groups. Patients with CD5+ DLBCL, however, showed higher rate of central nervous system relapse (33.3% vs 15.6%; P<.01) and a higher Ki67 proliferative index compared with CD5- patients. The median OS was significantly worse in CD5+ than CD5- patients (28.13 months vs not reached, P=.006). CD5 expression was an independent prognostic factor for OS in multivariate analysis. Conclusions R- EPOCH therapy does not seem to impact the known poorer prognosis of patients with de novo CD5+ DLBCL, and CD5 expression was still an independent prognostic factor in R- EPOCH-treated patients with DLBCL.
- Subjects
PROGNOSTIC tests; B cells; LYMPHOMA treatment; RITUXIMAB; CENTRAL nervous system
- Publication
European Journal of Haematology, 2017, Vol 98, Issue 4, p415
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.12847