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- Title
Spontaneous Closure of a Secundum Atrial Septal Defect.
- Authors
Wang, Stephen Y.; Welch, Terrence D.; Elfenbein, Aryé; Kaplan, Aaron V.
- Abstract
Spontaneous closure of an atrial septal defect (ASD) is well described in pediatric cardiology but may be less familiar to adult internists and cardiologists. We report a moderately sized 6-mm ASD that closed spontaneously without intervention. A literature review found that a smaller defect size and an early age of diagnosis are the most important predictors of closure. Possible mechanisms of a spontaneous ASD closure include adaptive endothelial migration, limited myocardial proliferation, and fibroblast migration with extracellular matrix deposition.
- Subjects
ATRIAL septal defect treatment; ATRIAL septal defects in children; PEDIATRIC cardiology; CARDIOLOGISTS; FIBROBLASTS; EXTRACELLULAR matrix
- Publication
Methodist DeBakey Cardiovascular Journal, 2018, Vol 14, Issue 1, p60
- ISSN
1947-6094
- Publication type
Article
- DOI
10.14797/mdcj-14-1-60