We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Diffuse myocardial fibrosis in hypertrophic cardiomyopathy can be identified by cardiovascular magnetic resonance, and is associated with left ventricular diastolic dysfunction.
- Authors
Ellims, Andris H.; Iles, Leah M.; Liang-han Ling; Hare, James L.; Kay, David M.; Taylor, Andrew J.
- Abstract
Background: The presence of myocardial fibrosis is associated with worse clinical outcomes in hypertrophic cardiomyopathy (HCM). Cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) sequences can detect regional, but not diffuse myocardial fibrosis. Post-contrast T1 mapping is an emerging CMR technique that may enable the non-invasive evaluation of diffuse myocardial fibrosis in HCM. The purpose of this study was to non-invasively detect and quantify diffuse myocardial fibrosis in HCM with CMR and examine its relationship to diastolic performance. Methods: We performed CMR on 76 patients - 51 with asymmetric septal hypertrophy due to HCM and 25 healthy controls. Left ventricular (LV) morphology, function and distribution of regional myocardial fibrosis were evaluated with cine imaging and LGE. A CMR T1 mapping sequence determined the post-contrast myocardial T1 time as an index of diffuse myocardial fibrosis. Diastolic function was assessed by transthoracic echocardiography. Results: Regional myocardial fibrosis was observed in 84% of the HCM group. Post-contrast myocardial T1 time was significantly shorter in patients with HCM compared to controls, consistent with diffuse myocardial fibrosis (498 ± 80 ms vs. 561 ± 47 ms, p < 0.001). In HCM patients, post-contrast myocardial T1 time correlated with mean E/e' (r = -0.48, p < 0.001). Conclusions: Patients with HCM have shorter post-contrast myocardial T1 times, consistent with diffuse myocardial fibrosis, which correlate with estimated LV filling pressure, suggesting a mechanistic link between diffuse myocardial fibrosis and abnormal diastolic function in HCM.
- Subjects
MYOCARDIAL infarction; FIBROSIS; CARDIOMYOPATHIES; GADOLINIUM; HYPERTROPHY; HEART ventricle diseases; DIASTOLE (Cardiac cycle); ECHOCARDIOGRAPHY; CARDIAC hypertrophy; LEFT heart ventricle; HEART septum; MAGNETIC resonance imaging; PROBABILITY theory; TIME; CONTRAST media; DESCRIPTIVE statistics; DISEASE complications; DIAGNOSIS
- Publication
Journal of Cardiovascular Magnetic Resonance (BioMed Central), 2012, Vol 14, Issue 1, p76
- ISSN
1532-429X
- Publication type
Article
- DOI
10.1186/1532-429X-14-76