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- Title
Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development.
- Authors
Nierenberg, Andrew A; Kansky, Christine; Brennan, Brian P; Shelton, Richard C; Perlis, Roy; Iosifescu, Dan V
- Abstract
The article presents a review of mitochondrial modulators (MM) for the treatment of bipolar disorder and discusses the role of mitochondrial dysfunctions in the pathophysiology of bipolar disorder. The article reviews ‘candidate MMs’ which have the potential to improve mitochondrial function and brain energy metabolism including N-acetyl-cysteine (NAC), acetyl-L-carnitine (ALCAR), and S-adenosylmethionine (SAMe). The article also discusses the combination and clinical trials of MMs.
- Subjects
ADENOSYLMETHIONINE; CARNITINE; COENZYMES; DIETARY supplements; DRUG design; ENERGY metabolism; GENE expression; BIPOLAR disorder; MELATONIN; MITOCHONDRIA; CYSTEINE
- Publication
Australian & New Zealand Journal of Psychiatry, 2013, Vol 47, Issue 1, p26
- ISSN
0004-8674
- Publication type
Article
- DOI
10.1177/0004867412449303