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- Title
RIBES NIGRUM FRUIT EXTRACT SHOWS CARDIOPROTECTIVE PROPERTIES IN EXPERIMENTAL ACUTE ISCHEMIC HEART DISEASE.
- Authors
Gubina-Vakulyck, Galina I.; Gorbach, Tatyana V.; Tkachenko, Anton S.; Domarev, Anatolii P.; Martynova, Svitlana M.; Denysenko, Svitlana A.; Shcholok, Tatyana T.; Molchanova, Ann V.
- Abstract
The study was designed to assess antioxidant and cardioprotective properties of antioxidantscontaining blackcurrant (Ribes nigrum) extract in experimental adrenaline-induced acute ischemic heart disease. The content of troponin-1 and myoglobin, the activity of creatine phosphokinase MB in blood serum and levels of TBA-reactive substances, reduced glutathione and ATP, as well as the activity of superoxide dismutase, catalase, alanine aminotransferase and aspartate aminotransferase in myocardial homogenates were determined in control intact animals and in rats with adrenaline-induced acute ischemic heart disease untreated and treated with the blackcurrant extract. Our findings suggest that the Ribes nigrum fruit extract administration at a dose of 0.1 ml / 100g of body weight results in activation of antioxidant system and energy metabolism in myocardium and normalization of redox metabolism.
- Subjects
EUROPEAN black currant; PLANT extracts; CARDIOTONIC agents; CORONARY disease; CREATINE kinase
- Publication
Studia Universitatis Vasile Goldis Seria Stiintele Vietii (Life Sciences Series), 2018, Vol 28, Issue 3, p122
- ISSN
1584-2363
- Publication type
Article