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- Title
Advanced diffusion MRI and image texture analysis detect widespread brain structural differences between relapsing-remitting and secondary progressive multiple sclerosis.
- Authors
Oladosu, Olayinka; Wei-Qiao Liu; Brown, Lenora; Pike, Bruce G.; Metz, Luanne M.; Yunyan Zhang
- Abstract
Introduction: Disease development in multiple sclerosis (MS) causes dramatic structural changes, but the exact changing patterns are unclear. Our objective is to investigate the dierences in brain structure locally and spatially between relapsing-remitting MS (RRMS) and its advanced form, secondary progressive MS (SPMS), through advanced analysis of diusion magnetic resonance imaging (MRI) and image texture. Methods: A total of 20 patients with RRMS and nine patients with SPMS from two datasets underwent 3T anatomical and diusion tensor imaging (DTI). The DTI was harmonized, augmented, and then modeled, which generated six voxel- and sub-voxel-scale measures. Texture analysis focused on T2 and FLAIR MRI, which produced two phase-based measures, namely, phase congruency and weighted mean phase. Data analysis was 3-fold, i.e., histogram analysis of whole-brain normal appearing white matter (NAWM); region of interest (ROI) analysis of NAWM and lesions within three critical white matter tracts, namely, corpus callosum, corticospinal tract, and optic radiation; and along-tract statistics. Furthermore, by calculating the z-score of core-rim pathology within lesions based on diusion measures, we developed a novel method to define chronic active lesions and compared thembetween cohorts. Results: Histogram features from diusion and all but one texture measure dierentiated between RRMS and SPMS. Within-tract ROI analysis detected cohort dierences in both NAWM and lesions of the corpus callosum body in three measures of neurite orientation and anisotropy. Along-tract statistics detected cohort dierences frommultiplemeasures, particularly lesion extent, which increased significantly in SPMS in posterior corpus callosum and optic radiations. The number of chronic active lesions were also significantly higher (by 5-20% over z-scores 0.5 and 1.0) in SPMS than RRMS based on diusion anisotropy, neurite content, and diameter. Conclusion: Advanced diusion MRI and texture analysis may be promising approaches for thorough understanding of brain structural changes from RRMS to SPMS, thereby providing new insight into disease development mechanisms in MS.
- Subjects
TEXTURE analysis (Image processing); DIFFUSION magnetic resonance imaging; MAGNETIC resonance imaging; MULTIPLE sclerosis; CORPUS callosum
- Publication
Frontiers in Human Neuroscience, 2022, Vol 16, p1
- ISSN
1662-5161
- Publication type
Article
- DOI
10.3389/fnhum.2022.944908