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- Title
Community-Wide Universal HIV Test and Treat Intervention Reduces Tuberculosis Transmission in Rural Uganda: A Cluster-Randomized Trial.
- Authors
Marquez, Carina; Atukunda, Mucunguzi; Nugent, Joshua; Charlebois, Edwin D; Chamie, Gabriel; Mwangwa, Florence; Ssemmondo, Emmanuel; Kironde, Joel; Kabami, Jane; Owaraganise, Asiphas; Kakande, Elijah; Ssekaynzi, Bob; Abbott, Rachel; Ayieko, James; Ruel, Theodore; Kwariisima, Dalsone; Kamya, Moses; Petersen, Maya; Havlir, Diane V; Balzer, Laura B
- Abstract
Background Human immunodeficiency virus (HIV) treatment reduces tuberculosis (TB) disease and mortality; however, the population-level impact of universal HIV-test-and-treat interventions on TB infection and transmission remain unclear. Methods In a sub-study nested in the SEARCH trial, a community cluster-randomized trial (NCT01864603), we assessed whether a universal HIV-test-and-treat intervention reduced population-level incident TB infection in rural Uganda. Intervention communities received annual, population-level HIV testing and patient-centered linkage. Control communities received population-level HIV testing at baseline and endline. We compared estimated incident TB infection by arms, defined by tuberculin skin test conversion in a cohort of persons aged 5 and older, adjusting for participation and predictors of infection, and accounting for clustering. Results Of the 32 trial communities, 9 were included, comprising 90 801 participants (43 127 intervention and 47 674 control). One-year cumulative incidence of TB infection was 16% in the intervention and 22% in the control; SEARCH reduced the population-level risk of incident TB infection by 27% (adjusted risk ratio = 0.73; 95% confidence interval [CI]:.57–.92, P =.005). In pre-specified analyses, the effect was largest among children aged 5–11 years and males. Conclusions A universal HIV-test-and-treat intervention reduced incident TB infection, a marker of population-level TB transmission. Investments in community-level HIV interventions have broader population-level benefits, including TB reductions.
- Subjects
UGANDA; TUBERCULOSIS transmission; TUBERCULOSIS epidemiology; DIAGNOSIS of HIV infections; TUBERCULOSIS prevention; PREVENTION of infectious disease transmission; RESEARCH funding; STATISTICAL sampling; HIV infections; RANDOMIZED controlled trials; DESCRIPTIVE statistics; ODDS ratio; UNIVERSAL healthcare; RURAL conditions; TUBERCULIN test; MEDICAL screening; CONFIDENCE intervals
- Publication
Clinical Infectious Diseases, 2024, Vol 78, Issue 6, p1601
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciad776