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- Title
Chronic Active Epstein-Barr Virus (EBV) Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-Specific T Cells.
- Authors
Meedt, Elisabeth; Weber, Daniela; Bonifacius, Agnes; Eiz-Vesper, Britta; Maecker-Kolhoff, Britta; Delecluse, Susanne; Delecluse, Henri-Jacques; Lorenz, Myriam; Schwarz, Klaus; Meedt, Stefan T; Braess, Jan; Herr, Wolfgang; Holler, Ernst; Edinger, Matthias; Wolff, Daniel
- Abstract
We report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-year-old female patient treated with third-party EBV-specific T cells followed by allogeneic hematopoietic stem cell transplantation (HSCT). The viremia cleared after administration of anti-T-lymphocyte globulin for graft-versus-host disease (GvHD) prophylaxis. Subsequent expansion of EBV-infected host T cells was controlled by transfusion of donor-derived EBV-specific T cells.
- Subjects
TREATMENT of Epstein-Barr virus diseases; HOMOGRAFTS; GRAFT versus host disease; CHRONIC diseases; CELLS; VIREMIA; HEMATOPOIETIC stem cell transplantation; T cells; IMMUNOSUPPRESSIVE agents; DISEASE remission
- Publication
Clinical Infectious Diseases, 2023, Vol 76, Issue 12, p2200
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciad131