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- Title
Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination and Pediatric Age on Delta Variant Household Transmission.
- Authors
Ng, Oon Tek; Koh, Vanessa; Chiew, Calvin J; Marimuthu, Kalisvar; Thevasagayam, Natascha May; Mak, Tze Minn; Chua, Joon Kiat; Ong, Shannen Si Hui; Lim, Yong Kai; Ferdous, Zannatul; Johari, Alifa Khairunnisa bte; Cui, Lin; Lin, Raymond Tzer Pin; Tan, Kelvin Bryan; Cook, Alex R; Leo, Yee Sin; Lee, Vernon J M
- Abstract
Background In Singapore, quarantine of all close contacts with entry and exit polymerase chain reaction testing enabled evaluation of the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and pediatric age on transmission of the Delta variant. Methods This retrospective cohort study included all household close contacts between 1 March 2021 and 31 August 2021. Results Among 8470 Delta variant-exposed contacts linked to 2583 indices, full-vaccination of the index with BNT162b2 or mRNA-1273 was associated with reduction in acquisition by contacts (adjusted odds ratio [aOR], 0.56; 95% robust confidence interval [RCI],.44–.71 and aOR, 0.51; 95% RCI,.27–.96, respectively). Compared with young adults (aged 18–29 years), children (aged 0–11 years) were significantly more likely to transmit (aOR, 2.37; 95% RCI, 1.57–3.60) and acquire (aOR, 1.43; 95% RCI, 1.07–1.93) infection, vaccination considered. Longer duration from vaccination completion among contacts was associated with decline in protection against acquisition (first-month aOR, 0.42; 95% RCI,.33–.55; fifth-month aOR, 0.84; 95% RCI,.55–.98; P <.0001 for trend) and symptomatic disease (first-month aOR, 0.30; 95% RCI,.23–.41; fifth-month aOR, 0.62; 95% RCI,.38–1.02; P <.0001 for trend). Contacts immunized with mRNA-1273 had significant reduction in acquisition (aOR, 0.73; 95% RCI,.58–.91) compared with BNT162b2. Conclusions Among household close contacts, vaccination prevented onward SARS-CoV-2 transmission and there was in-creased risk of SARS-CoV-2 acquisition and transmission among children compared with young adults. Time after completion of vaccination and vaccine type affected SARS-CoV-2 acquisition.
- Subjects
HOME environment; SARS-CoV-2; IMMUNIZATION; COVID-19; CONFIDENCE intervals; COVID-19 vaccines; AGE distribution; RETROSPECTIVE studies; INFECTIOUS disease transmission; MESSENGER RNA; DESCRIPTIVE statistics; ODDS ratio; DATA analysis software; LONGITUDINAL method
- Publication
Clinical Infectious Diseases, 2022, Vol 75, Issue 1, pe35
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciac219