We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inherited Interleukin 2–Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma.
- Authors
Youssefian, Leila; Vahidnezhad, Hassan; Yousefi, Mehdi; Saeidian, Amir Hossein; Azizpour, Arghavan; Touati, Andrew; Nikbakht, Neda; Hesari, Kambiz Kamyab-; Adib-Sereshki, Mohammad Mahdi; Zeinali, Sirous; Mansoori, Behzad; Jazayeri, Ali; Karamzadeh, Razieh; Fortina, Paolo; Jouanguy, Emmanuelle; Casanova, Jean-Laurent; Uitto, Jouni
- Abstract
Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)–lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with β–human papillomavirus (HPV)–positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including β-HPV and EBV.
- Subjects
GENETICS of Epstein-Barr virus diseases; SIBLINGS; HODGKIN'S disease; INTERLEUKINS; LYMPHOPROLIFERATIVE disorders; GENETIC mutation; PROTEIN kinases; T cells; WARTS
- Publication
Clinical Infectious Diseases, 2019, Vol 68, Issue 11, p1938
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciy942