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- Title
Phagocytized apoptotic cells in subcutaneous panniculitis-like T-cell lymphoma.
- Authors
Ikeda, E; Endo, M; Uchigasaki, S; Baba, S; Suzuki, H; Kinukawa, N; Nemoto, N
- Abstract
Abstract We reported on a case of subcutaneous panniculitis-like T-cell lymphoma (SPTCL) with multiple erythematous nodular lesions on the extremities, trunk and face. Histological examination of an excised lesion revealed a dense infiltrate of markedly atypical T-lymphoid cells expressing the CD8+ phenotype located in the subcutaneous tissue with histiocyte-phagocytizing apoptotic cells. The ‘bean-bag’ histiocytic cells, the characteristic finding of SPTCL, are considered to be products of haemophagocytosis. In our case the ‘bean-bag’ cells were produced by phagocytosis of apoptotic bodies, as confirmed by electron microscopy. It is suspected that ‘bean-bag’ cells are related not to haemophagocytosis but to phagocytosis of apoptotic cells in the CD8+ T-cell type of SPTCL.
- Subjects
LYMPHOMAS; DRUG therapy; RETICULOENDOTHELIAL granulomas; PHYSIOLOGY
- Publication
Journal of the European Academy of Dermatology & Venereology, 2001, Vol 15, Issue 2, p159
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1046/j.1468-3083.2001.00230.x