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- Title
Syndecans play dual roles as cell adhesion receptors and docking receptors
- Authors
Kwon, Mi-Jung; Jang, Bohee; Yi, Jae Youn; Han, Inn-Oc; Oh, Eok Soo
- Abstract
Abstract: Syndecan are a family of cell surface heparan sulfate proteoglycans that act as cell surface receptors. Most cell surface receptors have a limited number and type of ligand interactions, responding only to the binding of (a) specific ligand(s). In contrast, syndecans can interact with various numbers and types of ligands, and thus play more diverse roles than others. Various syndecan functions have not yet been fully classified and categorized, but we herein review previous studies suggesting that syndecans play dual function as cell surface receptors by acting as both adhesion receptors and docking receptors. Through this dual regulatory function, syndecans are capable of regulating both intra- and extracellular activities, potentially altering a variety of cell behaviors.
- Subjects
SYNDECANS; CELL adhesion; CELL membranes; PROTEOGLYCANS; LIGAND binding (Biochemistry); PROTEIN-protein interactions; EXTRACELLULAR matrix proteins; TRANSFORMING growth factors-beta
- Publication
FEBS Letters, 2012, Vol 586, Issue 16, p2207
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.05.037