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- Title
LKB1 loss of function studied in vivo
- Authors
Shorning, Boris Y.; Clarke, Alan R.
- Abstract
Abstract: Recent developments have placed the serine/threonine kinase LKB1 on the crossroads linking energy metabolism, cell structure and cancer progression and that its deletion can affect tumorigenesis, metastasis, cell adhesion and polarity. LKB1 can regulate a host of different functions which all have potential to impact upon the initiation and progression of neoplastic disease. To understand the phenotypic consequences of LKB1 loss in a range of different settings, a number of animal models of loss of function have been generated and analyzed. In this review we summarize recent data generated from a range of these models, which reveal clear tissue specific differences in LKB1 function in vivo and in the consequences of its loss.
- Subjects
PROTEIN kinases; ENERGY metabolism; CANCER invasiveness; METASTASIS; ANIMAL models in research; CELL adhesion; CELL polarity
- Publication
FEBS Letters, 2011, Vol 585, Issue 7, p958
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2011.01.019