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- Title
The tumor microenvironment of benign and malignant salivary gland tumors.
- Authors
Wai, Katherine C.; Okholm, Trine Line H.; Ha, Patrick K.; Marquez, Diana M.; Tenvooren, Iliana; Jones, Kyle B.; Spitzer, Matthew H.
- Abstract
Background: Treatment of salivary gland tumors (SGTs) remains challenging. Little is known about the immune landscape of SGTs. We aimed to characterize the tumor microenvironment in benign and malignant SGTs. Methods: Eleven benign and nine malignant tumors were collected from patients undergoing curative intent surgery. Specimens were analyzed using mass cytometry by time‐of‐flight. Immune cell populations were manually gated, and T cells were clustered using the FlowSOM algorithm. Population frequencies were compared between high‐grade and low‐grade malignancies, corrected for multiple hypothesis testing. Results: There were trends towards increased CD4+ and CD8+ T cells among malignant tumors. High‐grade malignancies exhibited trends towards higher frequencies of CD8+ PD‐1+ CD39+ CD103+ exhausted T cells, CD4+ FoxP3+ TCF‐1+ CD127− Tregs, and CD69+ CD25− CD4+ T cells compared to low‐grade malignancies. Conclusion: SGTs exhibit significant immunologic diversity. High‐grade malignancies tended to have greater infiltration of exhausted CD8+ T cells and Tregs, which may guide future studies for immunotherapy strategies.
- Subjects
BENIGN tumors; SALIVARY glands; T-cell exhaustion; TUMOR microenvironment; IMMUNOTHERAPY; REGULATORY T cells
- Publication
Head & Neck, 2024, Vol 46, Issue 7, p1625
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.27716