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- Title
Are oral cancers effectively palliated with radiotherapy? Outcomes of treatment with a modified QUAD SHOT regimen.
- Authors
Saha, Saheli; Mallick, Indranil; Mukherjee, Prattusha; Chakraborty, Santam; Bhattacharyya, Tapesh; S, Moses Arunsingh; Achari, Rimpa Basu; Chatterjee, Sanjoy
- Abstract
Background: This study assessed a palliative radiotherapy regimen using daily radiation over 4 days for three courses in inoperable head and neck cancers, emphasizing oral primary cancers. Methods: Retrospective data of 116 patients treated with a daily dose of 3.6–3.7 Gy in four fractions over 4 days to a total of three courses, with a 2‐week gap after every course, were analyzed for survival outcomes. A subgroup analysis was done for oral cancer. Results: Ninety‐nine (85%) completed three courses. Overall subjective response rate was 77%. Median overall survival and progression‐free survival were 12 months (95% confidence interval [CI]: 8–20) and 8 months (95% CI: 6–10), with numerically higher overall survival in oral cancer. The treatment was well tolerated, with no on‐treatment hospitalization or grade 3–4 toxicities. Conclusion: The modified QUAD SHOT regimen is practical for palliation in head and neck cancers.
- Subjects
ORAL cancer; HEAD &; neck cancer; PROGRESSION-free survival; OVERALL survival; SURVIVAL rate
- Publication
Head & Neck, 2024, Vol 46, Issue 6, p1270
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.27730