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- Title
Intra-articular buprenorphine after knee arthroscopy. A randomised, prospective, double-blind study.
- Authors
Varrassi, G; Marinangeli, F; Ciccozzi, A; Iovinelli, G; Facchetti, G; Ciccone, A
- Abstract
<bold>Background: </bold>Demonstration of peripheral opioid receptors in inflamed synovia supports the concept of peripheral opioid analgesia. The aim of this study was to evaluate the analgesic effect of intra-articular administration of buprenorphine after knee arthroscopy.<bold>Methods: </bold>In a double-blind randomised trial, 48 patients were assigned to four groups: group A patients received buprenorphine 100 micrograms i.a. and NaCl 0.9% i.m., group B patients received bupivacaine 0.25% 50 mg i.a. and NaCl 0.9% i.m., group C patients received NaCl 0.9% i.a. and buprenorphine 100 micrograms i.m., and group D patients received NaCl 0.9% i.a. and NaCl 0.9% i.m. Intensity of postoperative pain was evaluated by VAS at recovery (T0) and 1, 3, 6, 12, 24 h after operation (T1, T2, T3, T4, T5), at rest and during passive 10 degrees knee flexion. Total analgesic requirements and side effects related to study drugs were recorded.<bold>Results: </bold>The VAS scores were significantly higher in groups C and D than in group A and B patients. The differences were significant at T0, T1, T2 and T3. At T1, group C and D patients had greater analgesic requirement than groups A and B. No patients developed side effects.<bold>Conclusion: </bold>Intra-articular buprenorphine and i.a. bupivacaine, both produced equally good postoperative pain control and allowed a significant reduction of analgesic requirement after knee arthroscopy.
- Publication
Acta Anaesthesiologica Scandinavica, 1999, Vol 43, Issue 1, p51
- ISSN
0001-5172
- Publication type
journal article
- DOI
10.1034/j.1399-6576.1999.430112.x