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- Title
Brza metoda za genotipiziranje DEFB1 - 44C/G SNP-a kod brazilskih pacijenata s parodontitisom.
- Authors
Cimões, Renata; Cavalcanti de Siqueira, Rafael Rafael Amorim; Crovella, Sergio; Eleutério de Souza, Paulo Roberto; Donos, Nikos
- Abstract
Aim: Defensins are cationic antimicrobial peptides expressed in epithelial cells. Such peptides exhibit antibacterial, antifungal and antiviral properties, and are a component of the innate immune response. It has been suggested that they have a protective role in the oral cavity. This study evaluated the DEFB1 polymorphism in diabetic patients with or without periodontitis in comparison to healthy controls. Material and Methods: We used Hairpin-Shaped Primer (HP) assay to study the distribution of the -44 C/G SNP (rs1800972) in 119 human DNAs obtained from diabetic patients and healthy control patients. Results: The results indicate that there are no differences in distribution between groups and that in diabetic periodontitis patients the homozygous mutant could be found more frequently. Conclusion: Further studies are necessary in order to investigate the role of DEFB1 polymorphisms in diabetic periodontitis patients and the influence of the peptide in periodontal pathogens.
- Subjects
DEFENSINS; BASIC proteins; PEPTIDE antibiotics; EPITHELIAL cells; NATURAL immunity; HUMAN DNA; PERIODONTITIS
- Publication
Acta Stomatologica Croatica, 2014, Vol 48, Issue 3, p208
- ISSN
0001-7019
- Publication type
Article
- DOI
10.15644/asc48/3/5