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- Title
Thalassemia Major and Bone Loss: Things to Ponder.
- Authors
Mahakkanukrauh, Pasuk; Sinthubua, Apichat; Das, Srijit
- Abstract
Objective & aims: Thalassemia major (TM) is a hemolytic disorder which arises due to defect in the genes. While the incidence of the disease increases globally, much needs to be understood with respect to the bone loss which occurs in this disease. Osteoporosis seen in TM patients throw up a huge challenge for treatment as it affects the younger age group. The present review aimed to describe the bone loss due to various pathological mechanisms in TM. Methods: A narrative review was done and all aspects of bone loss in TM were discussed. Design: The Pubmed and Google databases were searched for relevant articles on bone loss in TM patients. Results: Endocrinopathies, hormonal disturbances, genetic factors, signalling pathways and iron level may influence the condition of the bones in TM. Conclusion: All future treatment for bone loss in TM patients should consider the risk factors and aim at restoring the bone loss.
- Subjects
BONES; DISEASES; OSTEOPATHIC medicine; OSTEOPOROSIS; RISK assessment; THALASSEMIA; BETA-Thalassemia; DISEASE complications; DISEASE risk factors
- Publication
International Medical Journal, 2020, Vol 27, Issue 2, p185
- ISSN
1341-2051
- Publication type
Article