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- Title
Investigation of the Impact of Childhood Immune Imprinting on Birth Year-Specific Risk of Clinical Infection During Influenza A Virus Epidemics in Hong Kong.
- Authors
Tsang, Tim K; Gostic, Katelyn M; Chen, Sijie; Wang, Yifan; Arevalo, Philip; Lau, Eric H Y; Cobey, Sarah; Cowling, Benjamin J
- Abstract
Influenza imprinting reduces risks of influenza A virus clinical infection by 40%–90%, estimated from surveillance data in western countries. We analyzed surveillance data from 2010 to 2019 in Hong Kong. Based on the best model, which included hemagglutinin group-level imprinting, we estimated that individuals imprinted to H1N1 or H2N2 had a 17% (95% confidence interval [CI], 3%–28%) lower risk of H1N1 clinical infection, and individuals imprinted to H3N2 would have 12% (95% CI, −3% to 26%) lower risk of H3N2 clinical infection. These estimated imprinting protections were weaker than estimates in western countries. Identifying factors affecting imprinting protections is important for control policies and disease modeling.
- Subjects
HONG Kong (China); INFLUENZA A virus; INFLUENZA viruses; VIRUS diseases; EPIDEMICS; WESTERN countries
- Publication
Journal of Infectious Diseases, 2023, Vol 228, Issue 2, p169
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad009