We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Insights in intestinal immune tolerance: The role of the cleavage form of gasdermin D.
- Authors
Rossi, Federico; Votto, Martina; Castagnoli, Riccardo
- Abstract
The article discusses the role of the protein gasdermin D (GSDMD) in intestinal epithelial cells (IECs) and its implications for immune tolerance in the gut. GSDMD, known for its involvement in cell death, has been found to have a new function in IECs. When cleaved into a 13-kD N-terminal form, GSDMD translocates to the nucleus and interacts with STAT1, promoting the expression of MHCII molecules and enhancing immune tolerance to dietary antigens. The study also highlights the link between IECs and the antigen-presenting capacity to T cells, specifically Type 1 regulatory T cells (Tr1 cells). The findings suggest that targeting the GSDMD pathway could potentially be used in therapies for food allergies. However, further research is needed to fully understand the mechanisms of food tolerance and the activation of CASP-3/7 by food peptides.
- Subjects
IMMUNOLOGICAL tolerance; INTESTINES; REGULATORY T cells; T helper cells; HUMAN body
- Publication
Allergy, 2024, Vol 79, Issue 6, p1631
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.16076