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- Title
Lazarus's Gate: Challenges and Potential of Epigenetic Reprogramming of Somatic Cells.
- Authors
Henderson, J. T.
- Abstract
The past year has seen tremendous advances in epigenetic reprogramming of somatic cells. Direct genesis of pluripotent stem cells, in contrast to earlier somatic cell nuclear transfer (SCNT) techniques, removes significant ethical and regulatory concerns regarding the utilization of human oocytes and zygotes, and represents a significant step toward the development of nonxenogeneic production methods. While significant technical hurdles remain, this and related technologies are enabling new approaches toward clinical treatments, basic research and diagnostics, and drug evaluation.Clinical Pharmacology & Therapeutics (2008); 83, 6, 889–893 doi:10.1038/clpt.2008.51
- Subjects
PHYSIOLOGICAL effects of chemicals; CLINICAL pharmacology; SOMATIC cells; STEM cells; OVUM; ZYGOTES
- Publication
Clinical Pharmacology & Therapeutics, 2008, Vol 83, Issue 6, p889
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1038/clpt.2008.51