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- Title
Polymorphisms of ACE2 Gene are Associated With Essential Hypertension and Antihypertensive Effects of Captopril in Women.
- Authors
Fan, X.; Wang, Y.; Sun, K.; Zhang, W.; Yang, X.; Wang, S.; Zhen, Y.; Wang, J.; Li, W.; Han, Y.; Liu, T.; Wang, X.; Chen, J.; Wu, H.; Hui, R.
- Abstract
ACE2 appears to counterbalance the vasopressor effect of angiotensin I converting enzyme (ACE) in the renin–angiotensin system. We hypothesized that ACE2 polymorphisms could confer a high risk of hypertension and have an impact on the antihypertensive response to ACE inhibitors. The hypothesis was tested in two case–control studies and a clinical trial of 3,408 untreated hypertensive patients randomized to Atenolol, Hydrochlorothiazide, Captopril, or Nifedipine treatments for 4 weeks. ACE2 rs2106809 T allele was found to confer a 1.6-fold risk for hypertension in women (95% confidence interval (CI), 1.13–2.06), whereas when combined with the effect of the ACE DD genotype, the risk was 2.34-fold (95% CI, 1.75–4.85) in two independent samples. The adjusted diastolic blood pressure response to Captopril was 3.3 mm Hg lower in ACE2 T allele carriers than in CC genotype carriers (P=0.019) in women. We conclude that the ACE2 T allele confers a high risk for hypertension and reduced antihypertensive response to ACE inhibitors.Clinical Pharmacology & Therapeutics (2007) 82, 187–196. doi:10.1038/sj.clpt.6100214; published online 2 May 2007
- Subjects
ANGIOTENSINS; MEDICAL sciences; THERAPEUTICS; CLINICAL pharmacology; HYPERTENSION
- Publication
Clinical Pharmacology & Therapeutics, 2007, Vol 82, Issue 2, p187
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1038/sj.clpt.6100214