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Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis.
Published in:
2012
By:
- Lowe CE;
- Dennis RJ;
- Obi U;
- O'Rahilly S;
- Rochford JJ;
- Lowe, C E;
- Dennis, R J;
- Obi, U;
- O'Rahilly, S;
- Rochford, J J
Publication type:
journal article
Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution.
Published in:
1997
By:
- Montague CT;
- Prins JB;
- Sanders L;
- Digby JE;
- O'Rahilly S;
- Montague, C T;
- Prins, J B;
- Sanders, L;
- Digby, J E;
- O'Rahilly, S
Publication type:
journal article
Human obesity as a heritable disorder of the central control of energy balance.
Published in:
2008
By:
- O'Rahilly S;
- Farooqi IS;
- O'Rahilly, S;
- Farooqi, I S
Publication type:
journal article
IRS2 variants and syndromes of severe insulin resistance.
Published in:
2009
By:
- Bottomley, W.;
- Soos, M.;
- Adams, C.;
- Guran, T.;
- Howlett, T.;
- Mackie, A.;
- Miell, J.;
- Monson, J.;
- Temple, R.;
- Tenenbaum-Rakover, Y.;
- Tymms, J.;
- Savage, D.;
- Semple, R.;
- O’Rahilly, S.;
- Barroso, I.
Publication type:
Letter
PPARGC1A coding variation may initiate impaired NEFA clearance during glucose challenge.
Published in:
Diabetologia, 2007, v. 50, n. 3, p. 569, doi. 10.1007/s00125-006-0580-1
By:
- Franks, P.;
- Ekelund, U.;
- Brage, S.;
- Luan, J.;
- Schafer, A.;
- O’Rahilly, S.;
- Barroso, I.;
- Wareham, N.
Publication type:
Article
Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations.
Published in:
Diabetologia, 2007, v. 50, n. 3, p. 555, doi. 10.1007/s00125-006-0534-7
By:
- Collins, S.;
- Luan, J.;
- Thompson, A.;
- Daly, A.;
- Semple, R.;
- O’Rahilly, S.;
- Wareham, N.;
- Barroso, I.
Publication type:
Article
WNT10B mutations in human obesity.
Published in:
Diabetologia, 2006, v. 49, n. 4, p. 678, doi. 10.1007/s00125-006-0144-4
By:
- Christodoulides, C.;
- Scarda, A.;
- Granzotto, M.;
- Milan, G.;
- Nora, E. Dalla;
- Keogh, J.;
- De Pergola, G.;
- Stirling, H.;
- Pannacciulli, N.;
- Sethi, J. K.;
- Federspil, G.;
- Vidal-Puig, A.;
- Farooqi, I. S.;
- O’Rahilly, S.;
- Vettor, R.
Publication type:
Article
Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes.
Published in:
Diabetologia, 2006, v. 49, n. 3, p. 501, doi. 10.1007/s00125-005-0130-2
By:
- Barroso, I.;
- Luan, J.;
- Sandhu, M. S.;
- Franks, P. W.;
- Crowley, V.;
- Schafer, A. J.;
- O'Rahilly, S.;
- Wareham, N. J.
Publication type:
Article
Large-scale studies of the association between variation at the TNF/ LTA locus and susceptibility to type 2 diabetes.
Published in:
Diabetologia, 2005, v. 48, n. 10, p. 2013, doi. 10.1007/s00125-005-1902-4
By:
- Zeggini, E.;
- Groves, C. J.;
- Parkinson, J. R. C.;
- Halford, S. R.;
- Owen, K. R.;
- Frayling, T. M.;
- Walker, M.;
- Hitman, G. A.;
- Levy, J. C.;
- O'Rahilly, S.;
- Hattersley, A. T.;
- McCarthy, M. I.
Publication type:
Article
Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.
Published in:
Diabetologia, 2004, v. 47, n. 12, p. 2168, doi. 10.1007/s00125-004-1575-4
By:
- Liew, C. F.;
- Groves, C. J.;
- Wiltshire, S.;
- Zeggini, E.;
- Frayling, T. M.;
- Owen, K. R.;
- Walker, M.;
- Hitman, G. A.;
- Levy, J. C.;
- O’Rahilly, S.;
- Hattersley, A. T.;
- Johnston, D. G.;
- McCarthy, M. I.
Publication type:
Article
Natural variants of human p85α phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity.
Published in:
Diabetologia, 2000, v. 43, n. 3, p. 321, doi. 10.1007/s001250050050
By:
- Baynes, K. C. R.;
- Beeton, C. A.;
- Panayotou, G.;
- Stein, R.;
- Soos, M.;
- Hansen, T.;
- Simpson, H.;
- O'Rahilly, S.;
- Shepherd, P. R.;
- Whitehead, J. P.
Publication type:
Article
Genetic factors in human obesity.
Published in:
Obesity Reviews, 2007, v. 8, p. 37, doi. 10.1111/j.1467-789X.2007.00315.x
By:
- Farooqi, I. S.;
- O'Rahilly, S.
Publication type:
Article
Associations between body composition, glycaemia and complement C3 in black African and white European men.
Published in:
2022
By:
- Reed, R.M.;
- Hakim, O.;
- Lockhart, S.;
- O'Rahilly, S.;
- Whyte, M.B.;
- Goff, L.M.
Publication type:
Abstract
Psychiatric co-morbidities in patients attending specialist obesity services in the UK.
Published in:
QJM: An International Journal of Medicine, 2006, v. 99, n. 5, p. 317, doi. 10.1093/qjmed/hcl041
By:
- A. Tuthill;
- H. Slawik;
- S. O'Rahilly;
- N. Finer
Publication type:
Article
The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models.
Published in:
QJM: An International Journal of Medicine, 2000, v. 93, n. 1, p. 7, doi. 10.1093/qjmed/93.1.7
By:
- Yeo, G.S.H.;
- Farooqi, I.S.;
- Challis, B.G.;
- Jackson, R.S.;
- O'Rahilly, S.
Publication type:
Article
Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.
Published in:
Molecular Psychiatry, 2014, v. 19, n. 12, p. 1341, doi. 10.1038/mp.2014.126
By:
- Ziauddeen, H;
- Chamberlain, S R;
- Nathan, P J;
- Koch, A;
- Maltby, K;
- Bush, M;
- Tao, W X;
- Napolitano, A;
- Skeggs, A L;
- Brooke, A C;
- Cheke, L;
- Clayton, N S;
- Sadaf Farooqi, I;
- O'Rahilly, S;
- Waterworth, D;
- Song, K;
- Hosking, L;
- Richards, D B;
- Fletcher, P C;
- Bullmore, E T
Publication type:
Article
Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.
Published in:
Molecular Psychiatry, 2013, v. 18, n. 12, p. 1287, doi. 10.1038/mp.2012.154
By:
- Ziauddeen, H;
- Chamberlain, S R;
- Nathan, P J;
- Koch, A;
- Maltby, K;
- Bush, M;
- Tao, W X;
- Napolitano, A;
- Skeggs, A L;
- Brooke, A C;
- Cheke, L;
- Clayton, N S;
- Sadaf Farooqi, I;
- O'Rahilly, S;
- Waterworth, D;
- Song, K;
- Hosking, L;
- Richards, D B;
- Fletcher, P C;
- Bullmore, E T
Publication type:
Article
Erratum: Digenic inheritance of severe insulin resistance in a human pedigree.
Published in:
2002
By:
- Savage, D B;
- Agostini, M;
- Barroso, I;
- Gurnell, M;
- Luan, J;
- Meirhaeghe, A;
- Harding, A-H;
- Ihrke, G;
- Rajanayagam, O;
- Soos, M A;
- George, S;
- Berger, D;
- Thomas, E L;
- Bell, J D;
- Meeran, K;
- Ross, R J;
- Vidal-Puig, A;
- Wareham, N J;
- O'Rahilly, S
Publication type:
Correction Notice
Mitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophy.
Published in:
2012
By:
- Sleigh A;
- Stears A;
- Thackray K;
- Watson L;
- Gambineri A;
- Nag S;
- Campi VI;
- Schoenmakers N;
- Brage S;
- Carpenter TA;
- Murgatroyd PR;
- O'Rahilly S;
- Kemp GJ;
- Savage DB;
- Sleigh, Alison;
- Stears, Anna;
- Thackray, Kerrie;
- Watson, Laura;
- Gambineri, Alessandra;
- Nag, Sath
Publication type:
journal article
Prenatal analysis of the insulin receptor gene in a family with leprechaunism.
Published in:
1995
By:
- Krook, A.;
- Bell, J. A.;
- Robertson, M. E.;
- Brueton, L.;
- O'Rahilly, S.
Publication type:
journal article
Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling.
Published in:
Diabetologia, 2011, v. 54, n. 5, p. 1057, doi. 10.1007/s00125-011-2066-z
By:
- Raffan, E.;
- Soos, M.;
- Rocha, N.;
- Tuthill, A.;
- Thomsen, A.;
- Hyden, C.;
- Gregory, J.;
- Hindmarsh, P.;
- Dattani, M.;
- Cochran, E.;
- Kaabi, J.;
- Gorden, P.;
- Barroso, I.;
- Morling, N.;
- O'Rahilly, S.;
- Semple, R.
Publication type:
Article
Leptin therapy in lipodystrophy.
Published in:
2010
By:
- Savage, D.;
- O’Rahilly, S.
Publication type:
Editorial
Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals.
Published in:
Diabetologia, 2009, v. 52, n. 11, p. 2345, doi. 10.1007/s00125-009-1508-3
By:
- Finucane, F.;
- Luan, J.;
- Wareham, N.;
- Sharp, S.;
- O’Rahilly, S.;
- Balkau, B.;
- Flyvbjerg, A.;
- Walker, M.;
- Højlund, K.;
- Nolan, J.;
- Savage, D.
Publication type:
Article
Mechanistic insights into insulin resistance in the genetic era.
Published in:
Diabetic Medicine, 2011, v. 28, n. 12, p. 1476, doi. 10.1111/j.1464-5491.2011.03463.x
By:
- Parker, V. E. R.;
- Savage, D. B.;
- O'Rahilly, S.;
- Semple, R. K.
Publication type:
Article
Severe insulin resistance due to anti-insulin antibodies: response to plasma exchange and immunosuppressive therapy.
Published in:
Diabetic Medicine, 2009, v. 26, n. 1, p. 79, doi. 10.1111/j.1464-5491.2008.02621.x
By:
- Greenfield, J. R.;
- Tuthill, A.;
- Soos, M. A.;
- Semple, R. K.;
- Halsall, D. J.;
- Chaudhry, A.;
- O'Rahilly, S.
Publication type:
Article
Successful treatment of Type B insulin resistance in a patient with otherwise quiescent systemic lupus erythematosus.
Published in:
2005
By:
- Coll AP;
- Morganstein D;
- Jayne D;
- Soos MA;
- O'Rahilly S;
- Burke J
Publication type:
Journal Article
Letters.
Published in:
2005
By:
- Simoens, S.;
- Foulon, E.;
- Dethier, M.;
- Mathieu, C.;
- Laekeman, G.;
- Brennan, A. M.;
- McNamara, B.;
- Plant, W. D.;
- O'Halloran, D. J.;
- Coll, A. P.;
- Morganstein, D.;
- Jayne, D.;
- Soos, M. A.;
- O'Rahilly, S.;
- Burke, J.
Publication type:
Letter
Genetic variants of insulin receptor substrate-1 (IRS-1) in syndromes of severe insulin resistance. Functional analysis of Ala513Pro and Gly1158Glu IRS-1.
Published in:
Diabetic Medicine, 2002, v. 19, n. 10, p. 804, doi. 10.1046/j.1464-5491.2002.00779.x
By:
- Berger, D.;
- Barroso, I.;
- Soos, M.;
- Yeo, G.;
- Schafer, A. J.;
- O'Rahilly, S.;
- Whitehead, J. P.
Publication type:
Article
Hypoglycemia due to an Insulin Binding Antibody in a Patient with an IgA-κ Myeloma.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2007, v. 92, n. 6, p. 2013, doi. 10.1210/jc.2007-0075
By:
- Halsall, D. J.;
- Mangi, M.;
- Fahie-Wilson, M. N.;
- Wark, G.;
- Mainwaring-Burton, R.;
- O’Rahilly, S.;
- Soos, M.
Publication type:
Article
Elevated plasma adiponectin in humans with genetically defective insulin receptors.
Published in:
2006
By:
- Semple, R K;
- Soos, M A;
- Luan, J;
- Mitchell, C S;
- Wilson, J C;
- Gurnell, M;
- Cochran, E K;
- Gorden, P;
- Chatterjee, V K K;
- Wareham, N J;
- O'Rahilly, S
Publication type:
journal article
Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism.
Published in:
2005
By:
- Semple, R K;
- Achermann, J C;
- Ellery, J;
- Farooqi, I S;
- Karet, F E;
- Stanhope, R G;
- O'rahilly, S;
- Aparicio, S A
Publication type:
journal article
Severe insulin resistance, diabetes mellitus, hypertriglyceridemia, and pseudoacromegaly.
Published in:
Journal of Clinical Endocrinology & Metabolism, 1996, v. 81, n. 10, p. 3465, doi. 10.1210/jc.81.10.3465
By:
- KUMAR, S.;
- DURRINGTON, P. N.;
- O'RAHILLY, S.;
- LAING, I.;
- HUMPHREYS, P. J.;
- OLUKOGA, A. O.;
- BHATNAGAR, D.;
- MACKNESS, M. I.;
- DAVIS, J. R.;
- BOULTON, A. J.
Publication type:
Article
Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance.
Published in:
1993
By:
- Flier, J S;
- Moller, D E;
- Moses, A C;
- O'Rahilly, S;
- Chaiken, R L;
- Grigorescu, F;
- Elahi, D;
- Kahn, B B;
- Weinreb, J E;
- Eastman, R
Publication type:
journal article
Identification of the Global Transcriptomic Response of the Hypothalamic Arcuate Nucleus to Fasting and Leptin.
Published in:
Journal of Neuroendocrinology, 2010, v. 22, n. 8, p. 915, doi. 10.1111/j.1365-2826.2010.02026.x
By:
- Jovanovic, Z.;
- Tung, Y. C. L.;
- Lam, B. Y. H.;
- O'Rahilly, S.;
- Yeo, G. S. H.
Publication type:
Article
The Effects of Neurokinin B upon Gonadotrophin Release in Male Rodents.
Published in:
Journal of Neuroendocrinology, 2010, v. 22, n. 3, p. 181, doi. 10.1111/j.1365-2826.2009.01951.x
By:
- Corander, M. P.;
- Challis, B. G.;
- Thompson, E. L.;
- Jovanovic, Z.;
- Loraine Tung, Y. C.;
- Rimmington, D.;
- Huhtaniemi, I. T.;
- Murphy, K. G.;
- Topaloglu, A. K.;
- Yeo, G. S. H.;
- O'Rahilly, S.;
- Dhillo, W. S.;
- Semple, R. K.;
- Coll, A. P.
Publication type:
Article
QUANTITATIVE MODELLING OF ENDOCRINE DISEASES AS EXEMPLIFIED BY DIABETES.
Published in:
Clinical Endocrinology, 1987, v. 26, n. 1, p. 107, doi. 10.1111/j.1365-2265.1987.tb03644.x
By:
- TURNER, R. C.;
- RUDENSKI, A. S.;
- HOLMAN, R. R.;
- MATTHEWS, D. R.;
- O'RAHILLY, S. P.
Publication type:
Article
A classification of videoconferencing related illness: the Zoomnotic diseases.
Published in:
QJM: An International Journal of Medicine, 2021, v. 114, n. 3, p. 159, doi. 10.1093/qjmed/hcaa316
By:
- Rowitch, D H;
- O'Rahilly, S;
- Smith, G C S
Publication type:
Article
Letter to Editor Response to: Is zoomnosis a human-driven human zoonosis? A call for action.
Published in:
QJM: An International Journal of Medicine, 2021, v. 114, n. 2, p. 143, doi. 10.1093/qjmed/hcab006
By:
- Rowitch, D H;
- O'Rahilly, S;
- Smith, G C S
Publication type:
Article
Orexin Expression is Regulated by α-Melanocyte-Stimulating Hormone.
Published in:
Journal of Neuroendocrinology, 2007, v. 19, n. 9, p. 703, doi. 10.1111/j.1365-2826.2007.01577.x
By:
- López, M.;
- Lage, R.;
- Tung, Y. C. L.;
- Challis, B. G.;
- Varela, L.;
- Virtue, S.;
- O'Rahilly, S.;
- Vidal-Puig, A.;
- Diéguez, C.;
- Coll, A. P.
Publication type:
Article
Is the defect in pro-hormone processing in Type 2 diabetes mellitus restricted to the β cell?
Published in:
Diabetic Medicine, 2001, v. 18, n. 1, p. 17, doi. 10.1046/j.1464-5491.2001.00397.x
By:
- Bano, G.;
- Rodin, D. A.;
- White, A.;
- O'rahilly, S.;
- Nussey, S. S.
Publication type:
Article
The metabolic syndrome: all in the mind?
Published in:
1999
By:
- O'Rahilly, S P
Publication type:
Journal Article
High Prevalence of Hepatitis C Infection in Afro-Caribbean Patients with Type 2 Diabetes and Abnormal Liver Function Tests.
Published in:
Diabetic Medicine, 1995, v. 12, n. 3, p. 244, doi. 10.1111/j.1464-5491.1995.tb00466.x
By:
- Gray, H.;
- Wreghitt, T.;
- Stratton, I.M.;
- Alexander, G.J.M.;
- Turner, R.C.;
- O'Rahilly, S.
Publication type:
Article
The Seventh Annual Meeting of the Anglo-Danish-Dutch Diabetes Group.
Published in:
Diabetic Medicine, 1989, v. 6, n. 9, p. 829, doi. 10.1111/j.1464-5491.1989.tb01290.x
By:
- O'Rahilly, S.;
- Bilous, R.
Publication type:
Article
The Sixth Annual Meeting of the Anglo-Danish-Dutch Diabetes Group or Fun in Fyn.
Published in:
Diabetic Medicine, 1989, v. 6, n. 3, p. 277, doi. 10.1111/j.1464-5491.1989.tb01161.x
By:
- Heller, S. R.;
- O'Rahilly, S.
Publication type:
Article
Early-onset Type 2 Diabetes vs Maturity-onset Diabetes of Youth: Evidence for the Existence of Two Discrete Diabetic Syndromes.
Published in:
Diabetic Medicine, 1988, v. 5, n. 3, p. 224, doi. 10.1111/j.1464-5491.1988.tb00974.x
By:
- O'Rahilly, S.;
- Turner, R. C.
Publication type:
Article
Diabetes Nomenclature: Classification or Grading of Severity?
Published in:
Diabetic Medicine, 1986, v. 3, n. 3, p. 216, doi. 10.1111/j.1464-5491.1986.tb00747.x
By:
- Turner, R. C.;
- Holman, R. R.;
- Matthews, D. R.;
- O'Rahilly, S. P.;
- Rudenski, A. S.;
- Braund, W. J.
Publication type:
Article
FTO expression is regulated by availability of essential amino acids.
Published in:
International Journal of Obesity, 2013, v. 37, n. 5, p. 744, doi. 10.1038/ijo.2012.77
By:
- Cheung, M K;
- Gulati, P;
- O'Rahilly, S;
- Yeo, G S H
Publication type:
Article
Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis.
Published in:
International Journal of Obesity, 2012, v. 36, n. 9, p. 1248, doi. 10.1038/ijo.2011.233
By:
- Lowe, C E;
- Dennis, R J;
- Obi, U;
- O'Rahilly, S;
- Rochford, J J
Publication type:
Article
The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation.
Published in:
Cell Death & Differentiation, 2009, v. 16, n. 5, p. 782, doi. 10.1038/cdd.2009.11
By:
- Boyle, K. B.;
- Hadaschik, D.;
- Virtue, S.;
- Cawthorn, W. P;
- Ridley, S. H.;
- O'Rahilly, S.;
- Siddle, K.
Publication type:
Article
ob gene mutations and human obesity.
Published in:
1998
By:
- Farooqi, S;
- Rau, H;
- Whitehead, J;
- O'Rahilly, S
Publication type:
journal article

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