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- Title
Modulation of prostaglandin metabolism by K-MAP and prevention of toxic effect of cyclosporin on pancreatic islet cells.
- Authors
Teraoka, Satoshi; Kawai, Tatsuo; Babazono, Tetsuya; Funchinoue, Shohei; Honda, Hiroshi; Nakajima, Ichiro; Fujikawa, Hiroyasu; Hayashi, Taketoshi; Nakagawa, Yoshihiko; Fujita, Shogo; Tojinbara, Tamotsu; Ota, Kazuo; Teraoka, S; Kawai, T; Babazono, T; Fuchinoue, S; Honda, H; Nakajima, I; Fujikawa, H; Hayashi, T
- Abstract
The injection of 25 mg/kg i.p. cyclosporin (CsA) for 3 wk caused marked functional and morphological deteriorations of pancreatic islet cells in Wistar rats that were prevented by the combined administration of p-aminobenzoic acid-N-D-mannoside sodium salt (K-MAP). In this article, the toxic effect of CsA on pancreatic islet cells and the preventive effect of K-MAP on CsA-associated islet cell toxicity were investigated. Prolonged hyperglycemia and depressed insulin secretion after the glucose challenge observed in CsA-treated rats could be prevented by the combined administration of 300 and 900 mg/kg K-MAP. Cytoplasmic vacuolizations and a decrease in the number of mitochondria, intact endoplasmic reticula, secretory granules, and insulin-positive cells, as revealed by peroxidase-antiperoxidase staining, could also be prevented by the administration of 900 mg/kg K-MAP. This preventive effect of K-MAP on CsA-associated islet cell toxicity may suggest the combined use of K-MAP with CsA in pancreas transplantation and treatment of insulin-dependent diabetes.
- Publication
Diabetes, 1989, Vol 38, p120
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.38.1.s120