We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Concanavalin A and alloxan interactions on glucose-induced insulin secretion and biosynthesis from islets of Langerhans.
- Authors
Virji, Mohamed A.; Steffes, Michael W.; Estensen, Richard D.; Virji, M A; Steffes, M W; Estensen, R D
- Abstract
The pretreatment of isolated islets of Langerhans with concanavalin A (Con A) completely blocks alloxan from suppressing the insulin release response to glucose. The lectin itself inhibits insulin secretion. This effect is dose dependent and reversible. Con A, however, has no protective action against the inhibition of glucose-induced insulin biosynthesis in islets exposed to alloxan. The protective action of Con A on alloxan toxicity is likely to be at the beta-cell surface at a membrane recognition site for glucose as a stimulus for secretion. The insulin biosynthetic effect of glucose appears to be mediated through a separate mechanism.
- Publication
Diabetes, 1984, Vol 33, Issue 2, p164
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.33.2.164