We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
(REH07) Systematic Review on Exercise Training as a Neuroplasticity-Inducing Behavior in Multiple Sclerosis.
- Authors
Jones, Catherine D.; Baird, Jessica F.; Motl, Robert W.; Sandroff, Brian M.
- Abstract
Background: Exercise training is associated with improvements in physical fitness, walking mobility, balance, and possibly cognition in persons with multiple sclerosis (MS), perhaps based on neuroplasticity. However, it is difficult to characterize exercise training as a neuroplasticity-inducing behavior among persons with MS based on changes in functional outcomes alone, as neuroplasticity reflects true brain-behavior relationships. Objectives: The current systematic review provided a critical evaluation of exercise training as a neuroplasticity-inducing behavior in persons with MS based on a well-established conceptual model. This involved prioritizing exercise training studies in persons with MS that included both functional and neuroimaging outcomes and further examined associations among these outcomes. Methods: We performed an open-dated search of online scholarly databases in July 2019 using a targeted and comprehensive search strategy. To be eligible for full-review, papers had to be published in English and include the following components: a) exercise training, b) neuroimaging outcomes, and c) functional outcomes (ie, measures of physical fitness, walking mobility, balance, and/or cognition) in persons with MS. Acceptable study designs included randomized controlled trials, single-group pre/post designs, and quasi-experimental designs. Four independent reviewers extracted relevant data from each eligible paper, including information on participant characteristics, exercise intervention characteristics, neuroimaging outcome characteristics, functional outcome characteristics, and pattern of study results. Results: The literature search returned only 9 papers (involving 7 original interventions) that met eligibility criteria wherein inferences regarding neuroplasticity could be drawn, based on the inclusion of both neuroimaging and functional end points. Within those 9 papers, there is mixed evidence for exercise training as a neuroplasticity-inducing behavior in persons with MS. Conclusions: There is insufficient data necessary to draw definitive conclusions on exercise as a neuroplasticity-inducing behavior in MS. Future research efforts might consider examining specific neural changes that would be expected to result from exercise prescriptions that are specifically designed to induce certain functional changes among persons with MS.
- Subjects
CONFERENCES &; conventions; EXERCISE; MULTIPLE sclerosis; NEUROPLASTICITY
- Publication
International Journal of MS Care, 2020, Vol 22, Issue S2, p70
- ISSN
1537-2073
- Publication type
Article