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- Title
MUC5B Idiopathic Pulmonary Fibrosis Risk Variant Promotes a Mucosecretory Phenotype and Loss of Small Airway Secretory Cells.
- Authors
Kurche, Jonathan S.; Cool, Carlyne D.; Blumhagen, Rachel Z.; Dobrinskikh, Evgenia; Heinz, David; Herrera, Jeremy A.; Yang, Ivana V.; Schwartz, David A.
- Abstract
The article discusses a study on how the MUC5B variant influences idiopathic pulmonary fibrosis (IPF) using a spatial gene expression approach. Topics include the dominant risk factor for the development of IPF, analysis of specimens, and implication of the loss of small airway secretory cells (SASC) markers in small airways of MUC5B variant carriers.
- Subjects
PHENOTYPES; METHACHOLINE chloride; PULMONARY fibrosis; CELL differentiation; AIRWAY (Anatomy); IDIOPATHIC pulmonary fibrosis
- Publication
American Journal of Respiratory & Critical Care Medicine, 2024, Vol 210, Issue 4, p517
- ISSN
1073-449X
- Publication type
Article
- DOI
10.1164/rccm.202311-2111LE