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- Title
GABA<sub>A</sub> receptors in aging and Alzheimer’s disease.
- Authors
Rissman, Robert A.; De Blas, Angel L.; Armstrong, David M.
- Abstract
In this article we present a comprehensive review of relevant research and reports on the GABAA receptor in the aged and Alzheimer’s disease (AD) brain. In comparison to glutamatergic and cholinergic systems, the GABAergic system is relatively spared in AD, but the precise mechanisms underlying differential vulnerability are not well understood. Using several methods, investigations demonstrate that despite resistance of the GABAergic system to neurodegeneration, particular subunits of the GABAA receptor are altered with age and AD, which can induce compensatory increases in GABAA receptor subunits within surrounding cells. We conclude that although aging- and disease-related changes in GABAA receptor subunits may be modest, the mechanisms that compensate for these changes may alter the pharmacokinetic and physiological properties of the receptor. It is therefore crucial to understand the subunit composition of individual GABAA receptors in the diseased brain when developing therapeutics that act at these receptors.
- Subjects
GABA; AMINO acid neurotransmitters; NEUROTRANSMITTERS; ALZHEIMER'S disease; PARASYMPATHOMIMETIC agents; PHARMACOKINETICS
- Publication
Journal of Neurochemistry, 2007, Vol 103, Issue 4, p1285
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1111/j.1471-4159.2007.04832.x