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- Title
Inhibitory effect and mechanism of action of tanshinone IIA on human bladder cancer cell J82.
- Authors
Xianjun Zhang; Ziwen Lu; Songzhe Piao; Tao Hong
- Abstract
Purpose: To investigate the therapeutic influence of tanshinone IIA on human bladder cancer cell J82, and the possible signal route involved. Methods: Cell proliferative potential was measured using MTT assay, while the expressions of associated genes were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and immunoblot assays. Results: Tanshinone IIA decreased J82 cell survival rate by > 42 % and inactivated apoptosis by suppressing PI3K/AKT/mTOR signal route. Moreover, it decreased Bcl-2, but upregulated caspase and Bax (p < 0.05). Conclusion: The inhibitory effect of TIIA on human bladder cancer suggests that TIIA can be developed into an anti-tumor agent.
- Subjects
BLADDER cancer; CANCER cells; SURVIVAL rate; CELL survival; CASPASES
- Publication
Tropical Journal of Pharmaceutical Research, 2021, Vol 20, Issue 4, p771
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v20i4.16