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- Title
Microvascular arterial disease of the brain and the heart: a shared pathogenesis.
- Authors
Bradley, C P; Berry, C
- Abstract
Microvascular arterial disease in the heart manifest as coronary microvascular dysfunction. This condition causes microvascular angina and is associated increased morbidity and mortality. Microvascular arterial disease in the brain is referred to as cerebrovascular small vessel disease. This is responsible for 45% of dementias and 25% of ischaemic strokes. The heart and brain share similar vascular anatomy and common pathogenic risk factors are associated with the development of both coronary microvascular dysfunction and cerebrovascular small vessel disease. Microvascular disease in the heart and brain also appear to share common multisystem pathophysiological mechanisms. Further studies on diagnostic approaches, epidemiology and development of disease-modifying therapy seem warranted.
- Subjects
INTRACRANIAL arterial diseases; CORONARY disease; MICROCIRCULATION disorders; ARTERIAL diseases; ISCHEMIC stroke; CEREBROVASCULAR disease
- Publication
QJM: An International Journal of Medicine, 2023, Vol 116, Issue 10, p829
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcad158