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- Title
Immunotherapy and cardiovascular diseases: novel avenues for immunotherapeutic approaches.
- Authors
Bonfiglio, C A; Weber, C; Atzler, D; Lutgens, E
- Abstract
As current therapies for cardiovascular disease (CVD), predominantly based on lipid lowering, still face an unacceptable residual risk, novel treatment strategies are being explored. Besides lipids, inflammatory processes play a major role in the pathogenesis of atherosclerosis, the underlying cause of the majority of CVD. The first clinical trials targeting the interleukin-1β-inflammasome axis have shown that targeting this pathway is successful in reducing cardiovascular events but did not decrease overall CVD mortality. Hence, novel and improved immunotherapeutics to treat CVD are being awaited.
- Subjects
CARDIOVASCULAR diseases; IMMUNOTHERAPY; INFLAMMATION; CLINICAL trials
- Publication
QJM: An International Journal of Medicine, 2023, Vol 116, Issue 4, p271
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcab207