We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Correlation between kidney and peripheral nerve functions in Type 2 diabetes.
- Authors
Lai, Y -R; Cheng, B -C; Huang, C -C; Chiu, W -C; Tsai, N -W; Chen, J -F; Lu, C -H
- Abstract
Background Although greater impairments in nerve functions parameters are most likely to occur with a lower kidney function, there is a paucity of information on the relationship between the kidney and peripheral nerve functions parameters in Type 2 diabetes. Aim To address the impact of peripheral nerve functions in Type 2 diabetes patients in different stages of chronic kidney diseases (CKD). Design This prospective study enrolled 238 patients with Type 2 diabetes at a tertiary medical center. Method We designed composite amplitude scores of nerve conductions (CAS) as a measure of severity of peripheral neuropathy (PN), and used estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR) parameters to stage CKD in Type 2 diabetes patients. The intrapersonal mean, standard deviation and coefficient of variation of eGFR for 238 patients were obtained in the 3 years prior to the study. Results The patients who had lower eGFR and higher UACR were older, with longer diabetes duration, a greater percentage of retinopathy and PN and higher CAS. Multiple linear regression analysis revealed that diabetes duration and eGFR were independently associated with CAS, and a cut-off value of eGFR in the presence of PN was 65.3 ml/min/1.73 m2. Conclusion We observed a close relationship between the severity of kidney and peripheral nerve function in patients with diabetes. If a patient's eGFR value is below 65.3 ml/min/1.73 m2 or the UACR value is above 98.6 mg/dl, caution is needed with the presence of PN even in diabetic patients who are asymptomatic.
- Subjects
TYPE 2 diabetes; PERIPHERAL nervous system; PEOPLE with diabetes; KIDNEYS; MULTIPLE regression analysis
- Publication
QJM: An International Journal of Medicine, 2020, Vol 113, Issue 3, p173
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcz249