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- Title
Urinary angiotensin converting enzyme 2 and disease activity in pediatric IgA nephropathy.
- Authors
Yuki Sakaki; Maki Urushihara; Takashi Nagai; Keisuke Fujioka; Shuji Kondo; Yukiko Kinoshita; Tomoki Hattori; Shoji Kagami
- Abstract
Background : Our previous studies demonstrated that the intrarenal renin-angiotensin system (RAS) status was activated in pediatric patients with chronic glomerulonephritis. In the present study, we tested the hypothesis that angiotensin-converting enzyme 2 (ACE2) expression in the kidney is associated with the development of pediatric IgA nephropathy. Methods : We analyzed urinary ACE2 levels and ACE2 expression in the kidney tissues of pediatric patients with IgA nephropathy treated with RAS blockade. Paired tests were used to analyze changes from the first to the second biopsy. Results : Urinary ACE2 levels were significantly decreased after RAS blockade treatment, accompanied by decreased ACE2 expression levels in kidney tissues, urinary protein levels and mesangial hypercellularity scores. Urinary ACE2 levels at the first biopsy were positively correlated with the ACE2 expression levels. Conclusions : These data suggest that urinary ACE2 is associated with ACE2 expression in the diseased kidney, which correlates with the pathogenesis of IgA nephropathy in pediatric patients.
- Subjects
ANGIOTENSIN converting enzyme; IMMUNOGLOBULIN A; RENIN-angiotensin system; TISSUE physiology; DATA analysis
- Publication
Journal of Medical Investigation, 2021, Vol 68, Issue 3/4, p292
- ISSN
1343-1420
- Publication type
Article
- DOI
10.2152/jmi.68.292