We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease.
- Authors
Alnima, T.; Meijer, R. I.; Spronk, H. M.H.; Warlé, M.; Cate, H. ten
- Abstract
Peripheral artery disease (PAD) is a major health problem with increased cardiovascular mortality, morbidity and disabling critical limb threatening ischemia (CLTI) and amputation. Diabetes mellitus (DM) and cigarette smoke are the main risk factors for the development of PAD. Although diabetes related PAD shows an accelerated course with worse outcome regarding complications, mortality and amputations compared with non-diabetic patients, current medical treatment does not make this distinction and includes standard antiplatelet and lipid lowering drugs for all patients with PAD. In this review we discuss the pathophysiologic mechanisms of PAD, with focus on differences in thrombo-inflammatory processes between diabetes-related and smoking-related PAD, and hypothesize on possible mechanisms for the progressive course of PAD in DM. Furthermore, we comment on current medical treatment and speculate on alternative medical drug options for patients with PAD and DM.
- Subjects
PERIPHERAL vascular diseases; THERAPEUTICS; CIGARETTE smoke; DIABETES; FOOT diseases; SMOKING
- Publication
Cardiovascular Diabetology, 2023, Vol 22, Issue 1, p1
- ISSN
1475-2840
- Publication type
Article
- DOI
10.1186/s12933-023-01990-6