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- Title
Reference genome of wild goat (capra aegagrus) and sequencing of goat breeds provide insight into genic basis of goat domestication.
- Authors
Yang Dong; Xiaolei Zhang; Min Xie; Arefnezhad, Babak; Zongji Wang; Wenliang Wang; Shaohong Feng; Guodong Huang; Rui Guan; Wenjing Shen; Bunch, Rowan; McCulloch, Russell; Qiye Li; Bo Li; Guojie Zhang; Xun Xu; Kijas, James W.; Salekdeh, Ghasem Hosseini; Wen Wang; Yu Jiang
- Abstract
Background: Domestic goats (Capra hircus) have been selected to play an essential role in agricultural production systems, since being domesticated from their wild progenitor, bezoar (Capra aegagrus). A detailed understanding of the genetic consequences imparted by the domestication process remains a key goal of evolutionary genomics. Results: We constructed the reference genome of bezoar and sequenced representative breeds of domestic goats to search for genomic changes that likely have accompanied goat domestication and breed formation. Thirteen copy number variation genes associated with coat color were identified in domestic goats, among which ASIP gene duplication contributes to the generation of light coat-color phenotype in domestic goats. Analysis of rapidly evolving genes identified genic changes underlying behavior-related traits, immune response and production-related traits. Conclusion: Based on the comparison studies of copy number variation genes and rapidly evolving genes between wild and domestic goat, our findings and methodology shed light on the genetic mechanism of animal domestication and will facilitate future goat breeding.
- Subjects
GOAT genetics; CAPRA aegagrus; DOMESTICATION of animals; DNA copy number variations; GOATS; ANIMAL breeding
- Publication
BMC Genomics, 2015, Vol 16, Issue 1, p1
- ISSN
1471-2164
- Publication type
Article
- DOI
10.1186/s12864-015-1606-1