We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The prognostic role of single cell invasion and nuclear diameter in early oral tongue squamous cell carcinoma.
- Authors
Almangush, Alhadi; Hagström, Jaana; Haglund, Caj; Kowalski, Luiz Paulo; Coletta, Ricardo D.; Mäkitie, Antti A.; Salo, Tuula; Leivo, Ilmo
- Abstract
Background: The clinical significance of single cell invasion and large nuclear diameter is not well documented in early-stage oral tongue squamous cell carcinoma (OTSCC). Methods: We used hematoxylin and eosin-stained sections to evaluate the presence of single cell invasion and large nuclei in a multicenter cohort of 311 cases treated for early-stage OTSCC. Results: Single cell invasion was associated in multivariable analysis with poor disease-specific survival (DSS) with a hazard ratio (HR) of 2.089 (95% CI 1.224–3.566, P = 0.007), as well as with disease-free survival (DFS) with a HR of 1.666 (95% CI 1.080–2.571, P = 0.021). Furthermore, large nuclei were associated with worse DSS (HR 2.070, 95% CI 1.216–3.523, P = 0.007) and with DFS in multivariable analysis (HR 1.645, 95% CI 1.067–2.538, P = 0.024). Conclusion: Single cell invasion and large nuclei can be utilized for classifying early OTSCC into risk groups.
- Publication
BMC Cancer, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2407
- Publication type
Article
- DOI
10.1186/s12885-024-11954-y