We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Atypical presentation of hairy cell leukemia: Significance of CD200 on flow cytometry.
- Authors
Rahman, Khaliqur; Kumari, Surabhi; Singh, Manish Kumar; Gupta, Ruchi; Yadav, Geeta; Kumari, Neeraj; Nityanand, Soniya; Nityan, Soniya
- Abstract
Hairy cell leukemia (HCL) is a rare, low-grade mature B-cell neoplasm with a characteristic clinical, morphological, immunophenotypic, and more recently described molecular (BRAF p.V600E mutation) profile. It typically affects middle-aged to elderly male who present with pancytopenia and massive splenomegaly. Lymphadenopathy is usually not seen. Atypical presentations such as absence of splenomegaly and presence of lymphadenopathy and leukocytosis, a hypoplastic marrow masquerading as aplastic anemia, pose a diagnostic challenge to both clinician and pathologist. A diligent morphological examination to look for the presence of hairy cells along with flow cytometric immunophenotyping showing consistent bright expression of CD200, in addition to well-described characteristic immunophenotype, helps in correctly diagnosing the case. This can be further confirmed by the consistent presence of V600E point mutation in BRAF gene. The correct identification of HCL in these unusual clinical presentations is of utmost importance owing to a different treatment approach in these cases. We present here four such cases with atypical presentation.
- Subjects
HAIRY cell leukemia; FLOW cytometry; LYMPHADENITIS; LEUCOCYTOSIS; IMMUNOPHENOTYPING; BRAF genes
- Publication
Journal of Cancer Research & Therapeutics, 2018, Vol 14, Issue 5, p1130
- ISSN
0973-1482
- Publication type
letter
- DOI
10.4103/0973-1482.188432