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- Title
Hypoxia induces an autocrine-paracrine survival pathway via platelet-derived growth factor (PDGF)-B/PDGF-Β receptor/phosphatidylinositol 3-kinase/Akt signaling in RN46A neuronal cells.
- Authors
Zhang, Shelley X.L.; Gozal, David; Sachleben Jr., Leroy R.; Rane, Madgavi; Klein, Jon B.; Gozal, Evelyne
- Abstract
Examines whether acute hypoxic stimuli will induce an autocrine-paracrine survival response in neurons. Element frequently occurring in brain disorders; Impact of hypoxia and minimum media growth conditions on differentiated RN46A neuronal cells; Motive for determining PDGF-B mRNA expression.
- Subjects
HYPOXEMIA; AUTOCRINE mechanisms; PARACRINE mechanisms; ENDOCRINOLOGY; NEURONS; BRAIN diseases
- Publication
FASEB Journal, 2003, Vol 17, Issue 12, p1709
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.02-1111fje