We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bone mass in young adults: relationship with gender, weight and genetic factors.
- Authors
Valero, C.; Zarrabeitia, M. T.; HernÁndez, J. L.; Zarrabeitia, A.; GonzÁlez-MacÍas, J.; Riancho, J. A.
- Abstract
Objectives. To determine the relationship of the bone mass attained in young adults with anthropometric and genetic factors. Design. Cross-sectional study of normal individuals. Methods. We studied 341 healthy subjects between 22 and 45 years of age. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) and correlated with body weight, height and nine polymorphisms in six genes involved in sex steroid metabolism (17-hydroxylase, aromatase and 5-reductase) and activity (oestrogen receptors (ER)- α and - β, and androgen receptor). Results. The BMD was higher in men than in women (spine: 1.048 ± 0.120 vs. 1.034 ± 0.112; hip: 0.907 ± 0.131 vs. 0.822 ± 0.104 g cm−2, P < 0.001). However, the difference was due, at least in part, to the larger body size in men and diminished markedly after height adjustment. There was a negative correlation between age and hip BMD. Body weight was the single most influential factor on spine and hip BMD in both sexes, explaining 8–9% of BMD variance. Amongst the genetic factors studied, a common CA repeat polymorphism in ER- β showed a significant association with BMD in women ( P = 0.03 at the spine, and 0.008 at the hip). The relationship between ER- β genotype and BMD persisted after adjustment by body weight and age, explaining a further 2–3% of BMD variance. Allelic variants of other genes studied were not related with BMD. Conclusions. Body weight and allelic variants of ER- β are associated with BMD in young adults.
- Subjects
ANDROGENS; SEX hormones; AROMATASE; OXIDOREDUCTASES; YOUNG adults; HUMAN body composition
- Publication
Journal of Internal Medicine, 2005, Vol 258, Issue 6, p554
- ISSN
0954-6820
- Publication type
Article
- DOI
10.1111/j.1365-2796.2005.01568.x